Police managed to keep pedestrians and traffic to a minimum in an area that is frequently packed an hour before midnight as firefighters dealt with the inferno.
The fire at the Bellagio Hotel on Thursday night led to the temporary closure of the boulevard.
The department said the building saw exterior damage. Authorities are investigating the cause of the fire.
The initial call was received at 10:46 PM local time, the CCFD said, and the first units arrived on the scene within five minutes.
He says damage was limited to the roof of the Via Bellagio annex. They added that strong winds had helped the fire spread quickly.
The hotel, which has almost 4,000 rooms, is one of the largest in the world.
Parts of the Las Vegas strip were shut down overnight due to a fire at the Bellagio Resort & Casino. Assistant Clark County Fire Chief Larry Haydu said foam building material fueled the flames, which did not reach inside the mall.
No injuries were reported and it was not necessary to evacuate the hotel.